MH 21312. These data document a high level of interindividual variability in the development of exercise-induced reproductive dysfunction, delineate the progression of changes in reproductive hormone secretion that occur with exercise training, and illustrate an abrupt transition from normal cyclicity to an amenorrheic state in exercising individuals, that is not necessarily associated with weight loss. Epub 2014 May 30. Epub 2007 Jan 30. Results showed greater activity in right lateral orbitofrontal cortex, a region involved in processing negatively valenced emotional stimuli, in the follicular compared with luteal phase. 2. It occurs in non-primates such as cows, dogs, etc. 2014;1(2):4. doi: 10.15226/2374-6890/1/2/00108. 2001 Nov;86(11):5184-93. doi: 10.1210/jcem.86.11.8024. However, longitudinal studies have been needed to examine individual susceptibility to exercise-induced reproductive dysfunction and to elucidate the progression of changes in reproductive function that occur with strenuous exercise training. This study investigated the estrogenic effect of Pueraria mirifica (P. mirifica) on menstrual cycle length and hormone-related ovarian function. J Clin Endocrinol Metab. Mean hormonal concentrations followed patterns previously demonstrated in primates, with a typical late follicular phase estrogen peak preceeding the ovulatory LH and FSH surges. Atypical estradiol secretion and ovulation patterns caused by luteal out-of-phase (LOOP) events underlying irregular ovulatory menstrual cycles in the menopausal transition. These included significant declines in plasma reproductive hormone concentrations, an increase in follicular phase length, and a decrease in luteal phase progesterone secretion. Slater J, Brown R, McLay-Cooke R, Black K. Sports Med. Helmond FA, Simons PA, Hein PR 1980 The effects of progesterone on estrogen-induced luteinizing hormone and follicle-stimulating hormone release in the female rhesus monkey Please enable it to take advantage of the complete set of features! For the concentration of 0.25 mg/ml PCP the range of days for the menstrual cycle was 25–29 days for monkey M-M; 23–28 days for M-L; and 23–28 days for M-P. The average length of the menstrual cycle in the mating season was 26.3 ±5.4 days. Twelve adult female crab-eating monkeys (Macaca fascicularis) were placed in six pairs of adjacent cages, allowing physical contact between members of these experimental pairs. It consists of a short period of oestrous or heat (e.g., 12-24 hours in cow) followed by anoestrous or passive Exercise induces two types of human luteal dysfunction: confirmation by urinary free progesterone. Theriogenology. Physical exercise and menstrual cycle alterations. 2008 Jul 1;70(1):1-14. doi: 10.1016/j.theriogenology.2008.03.001. sex behavior primate female menstrual cycle rhesus monkey This work (Publication No. Evidence for a causal role of low energy availability in the induction of menstrual cycle disturbances during strenuous exercise training. Comparison of the vaginal environment of Macaca mulatta and Macaca nemestrina throughout the menstrual cycle. COVID-19 is an emerging, rapidly evolving situation. HHS Hunnell NA, Rockcastle NJ, McCormick KN, Sinko LK, Sullivan EL, Cameron JL. When 0.5 mg/ml PCP was self-administered, number of days of menstrual cycles ranged from 23–32 for … Changes in electrical impedance of the vaginal medium during the menstrual cycle were recorded in female Rhesus monkeys using electrical probe and were correlated with estradiol-17 beta and progesterone plasma concentrations. Micro-sections from ovaries of autopsied animals revealed large Graafian follicle formations often rupturing by day fourteen of the cycle. COVID-19 is an emerging, rapidly evolving situation. 6. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Med Sci Sports Exerc. Consistent changes in function of the reproductive axis occurred abruptly, one to two menstrual cycles before the development of amenorrhea. This site needs JavaScript to work properly. Endocrinology (under submission) 2. [email protected] 2017;105(1):77-89. doi: 10.1159/000448520. Am J Reprod Immunol. Data regarding the menstrual cycle of various Primates are summarized in Table II. Female does not permit copulation during menstrual phase of the cycle. First, the menstrual cycle of the female rhesus monkey is very similar to that described in women (Knobil, 1974, Knobil and Hotchkiss, 1988). Almost all the monkeys had regular menstrual cycles only in the mating season, and had no menstrual cycles, or only irregular ones, in the non-mating season. The findings indicated that fluctuations in ovarian steroids are accompanied by behavioral changes in vervet monkeys. 2020 Jan 1;105(1):185-93. doi: 10.1210/clinem/dgz030. USA.gov. As monkeys gradually increased running to 12.3 +/- 0.9 km/day, body weight did not change significantly although food intake remained constant. Current Status of the Female Athlete Triad: Update and Future Directions. Estradiol Upregulates Kisspeptin Expression in the Preoptic Area of both the Male and Female Rhesus Monkey (Macaca mulatta): Implications for the Hypothalamic Control of Ovulation in Highly Evolved Primates. From day 26 of the first menstrual cycle to day 7 of the next menstrual cycle, the serum estradiol level decreased gradually and reached a minimum. COX-1 immunostaining was mainly localized in the luminal epithelium and glandular epithelium near the lumen, and detected in all the stages during the menstrual cycle. Curr Osteoporos Rep. 2017 Dec;15(6):577-587. doi: 10.1007/s11914-017-0412-x. Many zoologists regard this as different from a "true" menstrual cycle. GLP-compliant monkey study to estimate hormonal NOEL (Chenault et al., 1993): Female cynomolgus monkeys (8 normally cycling animals/dose; 5-11 years old) were orally-treated with melengestrol acetate over 3 consecutive menstrual cycles (up to 105  |  Hormonal vaginal cytology of vervet monkeys. Clipboard, Search History, and several other advanced features are temporarily unavailable. J Clin Endocrinol Metab. Length of the menstrual cycle ranged from 26–38 days with a modal value of 28 days. Nine normal cyclic monkeys (Macaca fascicularis) were separated into 3 groups; each group was force fed with a single Second, rhesus monkeys are capable of performing complex cognitive tasks (Washburn and Rumbaugh, 1991 Changes in LH, FSH, estrogens and progesterone were monitored daily. Vaginal swabs for menstrual blood were performed 3 times/week to determine the stage of the reproductive cycle. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Author information: (1)Division of Neuroscience, Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322, USA.  |  USA.gov. HHS In addtion, a comprehensive description of the receptor-mediated, hormone-driven morphological changes during the menstrual cycle in the cynomolgus monkey (Macaca fascicularis) is given. Energy Availability Is Associated With Luteinizing Hormone Pulse Frequency and Induction of Luteal Phase Defects. 1990 Oct;10(4):218-35. doi: 10.2165/00007256-199010040-00002. NLM  |  NLM The reversal of the impedance gradient's sign was nearly concomitant with the appearance of a detectable plasma progesterone concentration. Across the menstrual cycle, significantly fewer errors were made in the SDR task during the LF phase, when E2 concentrations were high and P4 concentrations low. Epub 2016 Jul 25. Am J Physiol Endocrinol Metab. Changes in electrical impedance of the vaginal medium during the menstrual cycle were recorded in female Rhesus monkeys using electrical probe and were correlated with estradiol-17 beta and progesterone plasma concentrations. Singletary SJ, Kirsch AJ, Watson J, Karim BO, Huso DL, Hurn PD, Murphy SJ. Psychoneuroendocrinology. 2001 Aug;26(6):623-39. Academic Article Brachial artery endothelial function is stable across a menstrual and oral contraceptive pill cycle but lower in premenopausal women than in … Hale GE, Hughes CL, Burger HG, Robertson DM, Fraser IS. Impedance increased again during the first third of the luteal phase until day 21. menstrual cycle of the rhesus monkey. J Endocrinol Diabetes. Female aggressive behaviour was studied in a heterosexual group of compound-housed rhesus monkeys (Macaca mulatta) to determine (1) whether the frequency of agonistic encounters fluctuated across the menstrual cycle, and (2) if changes in aggression correlated with fluctuations in serum oestradiol (E2) and testosterone (T) levels or with increased social activity associated with mating … Reproductive Dysfunction from the Stress of Exercise Training is not Gender Specific: The "Exercise-Hypogonadal Male Condition". Using the female cynomolgus monkey (Macaca fascicularis), we documented changes in menstrual cyclicity and patterns of LH, FSH, estradiol, and progesterone secretion as the animals developed exercise-induced amenorrhea. Mean number of days in the entire menstrual cycle (total height of each bar), follicular phase (shaded portion of each bar), and luteal phase (open portion of each bar) for exercising monkeys which ovulated (n = 5) in the Sed, Cycle-2 and Cycle-1 menstrual cycles. Distribution across Menstrual Cycle Mean hourly rates of female proceptive behavior for each of the nine females composed a 28-day composite cycle. Lacreuse A(1), Verreault M, Herndon JG. Changes in electrical impedance of vaginal mucus during the menstrual cycle in cynomolgus monkeys (Macaca fascicularis). The menstrual cycle length of cynomolgus macaques (28–32 days) is similar to that of humans (28–30 days) and do not exhibit seasoning menstrual cycle in contrast to …  |  Clipboard, Search History, and several other advanced features are temporarily unavailable. De Souza MJ, Koltun KJ, Etter CV, Southmayd EA. Sports Med. 2009 Jan-Feb;16(1):50-9. doi: 10.1097/GME.0b013e31817ee0c2. RU-486 (RU), a synthetic steroid with antiprogesterone receptor activity, was used to study the role of progesterone in the normal menstrual cycle of rhesus monkeys. 2005 Nov;44(6):37-42. Beitins IZ, McArthur JW, Turnbull BA, Skrinar GS, Bullen BA. The menstrual cycle length of cynomolgus macaques (28–32 days) is similar to that of humans (28–30 days) and do not exhibit seasoning menstrual cycle in contrast to rhesus macaques (Weinbauer et al., 2008). In animals which undergo a sexual‐skin cycle the phase of swelling (folli‐cular phase) is generally longer and more variable than the phase of quiescence (luteal phase). Menstrual cycle phase was verified by calendar and radioimmunoassay of levels of luteinizing hormone and 17-beta estradiol. 2017 Feb;47(2):207-220. doi: 10.1007/s40279-016-0583-0. Nevertheless, in the model group monkeys, from day 19 (during which they had been isolated and restrained) until day 13 of the next menstrual cycle, the serum estradiol levels markedly decreased and then fluctuated at an obviously lower level. An ultrasound study of the effect of chronic lead exposure on endometrial cycle changes in the female cynomolgus monkey.  |  The menstrual cycles of 14 captive Talapoin monkeys (Miopithecus talapoin) were studied by making serial observations on the vaginal smears and sexual skin swellings for up to 15 months. Menopause. The menstrual cycle in the cynomolgus monkey consists of a 12 to 14 day follicular phase, a 3-day ovulatory phase, and a 14 to 16 day luteal phase (Weinbauer et al., 2008). Epub 2014 Feb 13. The Menstrual Cycle of the Primates XI-The part played by Oestrogenic Hormone in the Menstrual Cycle BY S. ZUCKERMAN, Beit Memorial Research Fellow From the Department of Human Anatomy, Oxford (Communicated by W. Le Gros Clark, F.R.S.-Received 31 March ) [Pla 18] The following paper is a record of a series of experiments which were. doi: 10.1152/ajpendo.00497.2006. We assessed the relationship between social behavior and the menstrual cycle in 11 adult female vervet monkeys (Cercopithecus aethiops sabaeus) living in an established, stable social group. Neuroendocrinology. Williams NI, Helmreich DL, Parfitt DB, Caston-Balderrama A, Cameron JL. Blood and urine were collected at weekly or biweekly intervals for a total of eight samples per monkey for analysis of serum 17β-estradiol, progesterone, parathyroid hormone (PTH), osteocalcin, bone-specific alkaline phosphatase (BSAP), and urinary CrossLaps™. RR 00167 to the Wisconsin Regional Primate Research Center and National Institute of Mental Health Grant No. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Potential applications of electrical impedance techniques in female mammalian reproduction. Oestrous Cycle: 1. Many monkeys had a tendency to have their own individual and relatively regular cycles. Twelve of these females menstruated and the mean duration of their cycle was32–9 days … Vargas Trujillo M, Kalil B, Ramaswamy S, Plant TM. What are the mechanisms? The menstrual cycle in the cynomolgus monkey consists of a 12-14 days follicular phase, a 3-day ovulatory phase, and a 14-16 days luteal phase [24]. Lack of correlation of vaginal impedance measurements with hormone levels in the rat. Fluctuations in spatial recognition memory across the menstrual cycle in female rhesus monkeys. Working memory, assessed with the DMS task, was not consistently altered based on previously characterized menstrual cycle phases. Using the female cynomolgus monkey (Macaca fascicularis), we documented changes in menstrual cyclicity and patterns of LH, FSH, estradiol, and progesterone secretion as the animals developed exercise-induced amenorrhea. The aim of this study was to examine immunohistochemically the expression pattern of COX-1, COX-2, mPGES and cPGES proteins in the endometrium of the rhesus monkey during the menstrual cycle. The cyclical changes in sexual skin swelling and/or coloration were detected only in adolescent females. Epub 2008 Apr 22. 15-08 of the Wisconsin Regional Primate Research Center) was supported by the following grants: National Institutes of Health Grant No. NIH 2014 Apr;71(4):322-9. doi: 10.1111/aji.12201. Fourteen adult female rhesus monkeys were observed for 1 complete menstrual cycle, five of them for 2 cycles. Hadzic SV, Wang X, Dufour J, Doyle L, Marx PA, Lackner AA, Paulsen DB, Veazey RS. Please contact [email protected] for licensing and other business inquires.  |  2007 Jun;292(6):E1520-5. 1985 Feb;17(1):56-72. Tsuchiya H, Ogonuki N, Yoshida T, Cho F, Yoshikawa Y, Ito M, Sankai T. Seier JV, Venter FS, Fincham JE, Taljaard JJ. NIH We conclude that in alcohol-naive female Macaque monkeys studied under controlled conditions, peak blood alcohol levels after a standard dose of alcohol do not vary as a function of phase of the menstrual cycle. The time spent training until amenorrhea developed varied widely among animals (7-24 months; mean = 14.3 +/- 2.2 months) and was not correlated with initial body weight, training distance, or food intake. Females of other species of placental mammal undergo estrous cycles, in which the endometrium is completely reabsorbed by the animal (covert menstruation) at the end of its reproductive cycle. Contemp Top Lab Anim Sci. Please enable it to take advantage of the complete set of features! A gradual decrease in impedance was observed during the follicular phase, the lowest values being observed between days 12-17 of the cycle. Physical activity of adult female rhesus monkeys (Macaca mulatta) across the menstrual cycle. Low Energy Availability in Exercising Women: Historical Perspectives and Future Directions. Twelve additional females remained singly caged (no physical contact allowed) and served as six control “pairs.” In both experimental and control pairs, one member had a history of regular menstrual cycles, … 1. Cross-sectional studies of exercise-induced reproductive dysfunction have documented a high proportion of menstrual cycle disturbances in women involved in strenuous exercise training. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. This site needs JavaScript to work properly. The drug, at dosages of 2, 4, or 12 mg/kg, was administered as a single im injection during the luteal phase (days 5–8) in 16 experiments in 8 monkeys. These results support the use of vaginal impedance measurements as a help for the diagnosis of the periovulatory time in the female Rhesus monkey. Koltun KJ, De Souza MJ, Scheid JL, Williams NI. J Clin Endocrinol Metab. Here, we use 18F-fluorodeoxyglucose positron emission tomography to monitor changes in resting brain glucose metabolism across the menstrual cycle in female rhesus monkeys. Where possible, differences between the macaque and human endometria are discussed. 1991 Jun;72(6):1350-8. doi: 10.1210/jcem-72-6-1350. Days 12-17 of the luteal phase Defects involved in strenuous exercise training Primates summarized. Sullivan EL, Cameron JL hormone levels in the mating season was ±5.4! 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